The Guelcher group focuses on the design and development of synthetic biomaterials for soft and hard tissue engineering and drug delivery. Engineering alginate as bioink for bioprinting. In our laboratory, an optimized gel constituting nebivolol with gellan gum, carbopol, and PEG 400 was developed for transdermal delivery and subsequently evaluated in albino rats. 4D Printing with Mechanically Robust, Thermally Actuating Hydrogels. Kim, W.S. certain disease conditions such as chronic wounds and tumors; this property can therefore be utilized for targeted drug delivery to cellular compartment or particular tissues [23]. The latter properties in combination with the bio/mucoadhesive nature of hydrogels can be utilized to confine them at the site of application for various biomedical applications [, Various gelators at different concentrations or time durations can be used to impart mechanical strength to the injectable hydrogels, and/or to optimize the release rate by controlling interactions between the hydrogel and entrapped agents. ; Thalib, B.; Ruslin, M.; Tung, T.D.X. ; Garland, M.J.; Migalska, K.; Majithiya, R.; McCrudden, C.M. Synthesis and characterization of grafted thermosensitive hydrogels for heating activated controlled release. The effects of iontophoresis and electroporation on transdermal delivery of buprenorphine from solutions and hydrogels. ; Aldhubiab, B.E. (a) Peptide-based hydrogels could be made antimicrobial through use of AMPs for gelation or incorporation of antimicrobial agents (NPs, metal ions, or antibiotics). ; Doan, B.D. Preventing waste of such a material requires both addressing the problems in the current usage and developing its utilization systems at locations where they are missing. Hyaluronic Acid (HA)-Polyethylene glycol (PEG) as injectable hydrogel for intervertebral disc degeneration patients therapy. Zardad, A.Z. Mater. Jain, S.; Valvi, P.U. ; Nair, A.B. The presence of PEG chains decreased the percent release tetramethylrhodamine-labeled dextran in the presence of proteolytic enzyme due to steric repulsion [, Gelatin has shown its ability to form nanocomplexes with different polymers via ionic complexation, graft polymerization, or Maillard reaction. ; Murphy, A.; Pohlhaus, P.D. The statements, opinions and data contained in the journal, © 1996-2021 MDPI (Basel, Switzerland) unless otherwise stated. Xu, J.; Strandman, S.; Zhu, J.X. ; Ko, J.; Jang, M.H. Cui, N.; Qian, J.; Xu, W.; Xu, M.; Zhao, N.; Liu, T.; Wang, H. Preparation, characterization, and biocompatibility evaluation of poly(Nɛ-acryloyl-L-lysine)/hyaluronic acid interpenetrating network hydrogels. Other examples of wounds that heal by secondary intention are dehisced surgical wounds and pressure ulcers/injuries. An, Y.H. Su, X.; Tan, M.J.; Li, Z.; Wong, M.; Rajamani, L.; Lingam, G.; Loh, X.J. Various polymeric network design strategies to create smart hydrogels with prompt responsiveness and improved mechanical properties for diverse applications have been reviewed elsewhere [, Various investigations have revealed the effectiveness of the pH-sensitive hydrogels included in oral dosage forms of chemotherapeutic agents, insulin, calcitonin, and interferon-β [, Superporous hydrogel (SAH) formulations possess good mechanical strength and faster swelling rates, suggesting them appropriate for oral drug delivery and biomedical applications [, A novel hydrogel fabricated from grafting polycaprolactone onto a methacrylic acid copolymer structure was utilized for the oral delivery of amifostine. ; Shah, J.; Nair, A.B. Preparation and evaluation of niosome gel containing acyclovir for enhanced dermal deposition. Cheng, Y.H. The drug molecule is either conjugated to the surface of the nanoparticles or encapsulated and protected inside the core. ; Leijten, J.; Khademhosseini, A.; Dana, R.; Annabi, N. Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications. ; Hsiao, M.H. Though research has been mainly directed towards macroscopic hydrogels, there is an ever-growing interest in micro and nanogels. ; et al. Gačanin, J.; Synatschke, C.V.; Weil, T. Biomedical Applications of DNA-Based Hydrogels. Vera-González, N.; Shukla, A. Dublin, March 08, 2021 (GLOBE NEWSWIRE) -- The "Hydrogels - Global Market Trajectory & Analytics" report has been added to ResearchAndMarkets.com's offering. ; Kim, S.; Park, N. Light-responsible DNA hydrogel-gold nanoparticle assembly for synergistic cancer therapy. Nanogels, or hydrogel nanoparticles, have gained tremendous interest as one of the most appealing nanoparticulate drug delivery systems in recent years since they combine unique hydrogel characteristics with submicron particle size. ; Shehata, T.M. [. Murdan, S. Electro-responsive drug delivery from hydrogels. Hydrogels are similar to hydrocolloid dressings in that they are designed to facilitate autolysis of necrotic tissue, but they differ in that they donate moisture to extensively dry wounds. ; Chou, H.S. Leg ulcers are of huge socio-economic importance costing the NHS over one billion pounds per year. ; Anis, A.; Banerjee, I.; Pramanik, K.; Bhattacharya, M.K. Hydrogel Bioink Reinforcement for Additive Manufacturing: A Focused Review of Emerging Strategies. ; Vyas, B.A. ; Brown, H.R. ; Aldawood, Z.; Bassir, S.H. ; Sung, K.C. Lin, J.; Zheng, S.Y. Development of Asialoglycoprotein Receptor-Targeted Nanoparticles for Selective Delivery of Gemcitabine to Hepatocellular Carcinoma. Xie, B.; Jin, L.; Luo, Z.; Yu, J.; Shi, S.; Zhang, Z.; Shen, M.; Chen, H.; Li, X.; Song, Z. ... HYDROGELS. Jacob, S.; Nair, A.B. Depending on the magnitude of the electric field, they may swell, deswell, or erode and provide pulsatile drug release. By continuing you agree to the use of cookies. Development of cytocompatible adipocytes from human adipose stem cells entrapped in varying molecular weights of oxidized alginate hydrogel was reported [, Creating a 3D vascularized architecture that supports cell viability due to enhanced oxygen permeation and nutrient transport continues to remain as a major hurdle in the field of bioengineering. Macedo, A.S.; Castro, P.M.; Roque, L.; Thomé, N.G. ; Veress, G.; Szekeres, M.; Illés, E.; Tombácz, E. Magnetic hyaluronate hydrogels: Preparation and characterization. Sharifzadeh, G.; Hosseinkhani, H. Biomolecule-Responsive Hydrogels in Medicine. Chirality-dependent cell adhesion and enrichment in Janus nanocomposite hydrogels. ; Kaltchev, M.G. Yadav, S.; Sharma, A.K. Copyright © 2014 The Authors. Al-Dhubiab, B.E. ; Murthy, S.N. Servant, A.; Methven, L.; Williams, R.P. The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs. ; Tekko, I.A. dos Santos, J.F. Erol, O.; Pantula, A.; Liu, W.; Gracias, D.H. Transformer Hydrogels: A Review. Examples include Aquaform (Maersk Medical) and Intrasite Gel (Smith and Nephew). Author to whom correspondence should be addressed. ; Chen, K.T. A review describing the structure, synthesis, properties, fabrication method, and tissue engineering applications of hydrogels has been recently published [, Due to biodegradable and biocompatible characteristics, triblock polymers of PLA–poly(ethylene oxide)–PLA are employed as drug delivery carriers and tissue scaffolds [. [78] described a material composed of a cotton gauze, or other fibrous substrate, impregnated with a thermoplastic hydrogel forming polymer. Fiorica, C.; Pitarresi, G.; Palumbo, F.S. ; Park, E.K. Dalmoro, A.; Sitenkov, A.Y. Wells, L.A.; Lasowski, F.; Fitzpatrick, S.D. ; Mieler, W.F. ; Kim, S.; Kim, S.H. ; Chung, L.Y. ; Gupta, S.; Repka, M.A. ; Kumar, P. Nanoscale Self-Assembly for Therapeutic Delivery. Cunniffe, G.M. Tóth, I.Y. Kim, B.J. ; Farag, A.; Vernon, B.L. Help us to further improve by taking part in this short 5 minute survey, 3DP Printing of Oral Solid Formulations: A Systematic Review, Transcriptome Analysis Identifies Novel Mechanisms Associated with the Antitumor Effect of Chitosan-Stabilized Selenium Nanoparticles, Semi-Crystalline Copolymer Hydrogels as Smart Drug Carriers: In Vitro Thermo-Responsive Naproxen Release Study, https://doi.org/10.3390/pharmaceutics13030357, Rational Design and Characterization of Hydrogels to Improve Pharmaceutical and Biomedical Applicability, http://creativecommons.org/licenses/by/4.0/, Hydrophilic monomers and hydrophobic comonomers, Free radical copolymerization of a hydrophilic monomer with a hydrophobic co-monomer, Absence of cross-linking agents and relative ease of production, Polyelectrolyte solution and multivalent ions of opposite charge, Ionic interaction through simple ion exchange mechanisms and complex formation, Cross-linking takes place at room temperature and physiological pH, Limited to ionic polymers and sensitive to impurities, Polymeric functional groups of high electron density with electron-deficient hydrogen atom, Self-assemble through secondary molecular interactions. Smart Hydrogels in Tissue Engineering and Regenerative Medicine. ; McCarthy, H.O. Lalatsa, A.; Emeriewen, K.; Protopsalti, V.; Skelton, G.; Saleh, G.M. Hydrogels are well adapted to accommodate these drugs in their polymeric networks to protect them from the acidic conditions of the stomach. Zhang, K.; Huang, D.; Yan, Z.; Wang, C. Heparin/collagen encapsulating nerve growth factor multilayers coated aligned PLLA nanofibrous scaffolds for nerve tissue engineering. Investigations have led to the advancement of a collagen scaffold with optimized composition, cross-linking density, and pore size distribution for bone regeneration in vivo in minimally loaded calvarial defects. Mar 05, 2021: 3D lab skin for chemicals testing, research and repair (Nanowerk News) A model system that recreates full-thickness human skin should allow more effective testing of pharmaceuticals and cosmetics, while avoiding the need for animal tests.The system effectively models the development, cellular structure and barrier properties of skin. ; Shah, J.; Jacob, S.; Saraiya, V.; Attimarad, M.; SreeHarsha, N.; Akrawi, S.H. ; Jheng, Y.H. ; Kenawy, E.S. Wang, G.; Hu, X.; Lin, W.; Dong, C.; Wu, H. Electrospun PLGA-silk fibroin-collagen nanofibrous scaffolds for nerve tissue engineering. ; Hung, K.H. ; Peppas, N.A. Such hydrogels could protect the drug from acidic and enzymatic degradation in the stomach to deliver the drug to the intestine [, Forming polyelectrolyte complexes with natural anionic alginate polymer matrices and chitosan can control the drug release profile as well as inhibit the rapid decomposition of alginate at alkaline pH. Goodall, S.; Jones, M.L. Caló, E.; Khutoryanskiy, V.V. ; Ou, K.L. ; Cruciani, F.; Vitali, B.; Luppi, B. Chitosan/alginate complexes for vaginal delivery of chlorhexidine digluconate. Inflammation-Modulating Hydrogels for Osteoarthritis Cartilage Tissue Engineering. ; Peng, B.Y. All authors have read and agreed to the published version of the manuscript. Novel crosslinking methods to design hydrogels. ; Ramakrishna, S. Electrospun bio-composite P(LLA-CL)/collagen I/collagen III scaffolds for nerve tissue engineering. ; Lee, C.J. An effective delivery of a drug requires the nanoparticulate system to circumvent intracellular physiological barriers such as endosomes and deliver the drug directly within cytosol. Xu, X.; Zeng, Z.; Huang, Z.; Sun, Y.; Huang, Y.; Chen, J.; Ye, J.; Yang, H.; Yang, C.; Zhao, C. Near-infrared light-triggered degradable hyaluronic acid hydrogel for on-demand drug release and combined chemo-photodynamic therapy. ; van Nostrum, C.F. Yadollahi, M.; Gholamali, I.; Namazi, H.; Aghazadeh, M. Synthesis and characterization of antibacterial carboxymethyl cellulose/ZnO nanocomposite hydrogels. ; Manzo, R.H.; Jimenez-Kairuz, A.F. Burn injuries are one of the most common and devastating afflictions on the human body. Kim, S.J. Overstreet, D.J. Harsha, S.N. It was demonstrated that hydrogel-based microneedles provided prolonged transdermal drug administration and the release rate of the drug is mainly influenced by the cross-link density of the hydrogel polymer. Recent developments including synthetic processes of hydrogels and their biomedical applications as wound dressing materials are reviewed in the literature [ 157 ]. Jiang, T.; Wang, T.; Li, T.; Ma, Y.; Shen, S.; He, B.; Mo, R. Enhanced Transdermal Drug Delivery by Transfersome-Embedded Oligopeptide Hydrogel for Topical Chemotherapy of Melanoma. ; Rahul, V.G. Both chemical and physical approaches are used to enhance the transdermal permeation of actives [, Microneedle arrays fabricated from cross-linked hydrogel polymers upon insertion into the skin can absorb interstitial fluid to form continuous channels connecting to dermal circulation. The most frequently used biological materials for scaffold fabrication are collagen, various proteoglycans, alginate-based substrates, and chitosan. and S.J. Part B Appl. Topical buparvaquone nano-enabled hydrogels for cutaneous leishmaniasis. ; Kang-Mieler, J.J. Biodegradable Microsphere-Hydrogel Ocular Drug Delivery System for Controlled and Extended Release of Bioactive Aflibercept In Vitro. An injectable, click-crosslinked, cytomodulin-modified hyaluronic acid hydrogel for cartilage tissue engineering. Thermosensitive and mucoadhesive pluronic-hydroxypropylmethylcellulose hydrogel containing the mini-CD4 M48U1 is a promising efficient barrier against HIV diffusion through macaque cervicovaginal mucus. Google Patents US20130018110A1, 17 January 2013. The tensile strength needed from a drug-loaded hydrogel is usually based on the particular site and utilization of the hydrogel in high-stress locations such as cartilage tissue. The vaginal mucosal lining is also convenient for the absorption of diverse drugs including proteins and peptides for systemic effects, since it offers a high surface area and contains an extensive network of blood vessels. Chen, F.; Tian, M.; Zhang, D.; Wang, J.; Wang, Q.; Yu, X.; Zhang, X.; Wan, C. Preparation and characterization of oxidized alginate covalently cross-linked galactosylated chitosan scaffold for liver tissue engineering. ; writing–original draft preparation, J.S., N.S., S.G. and P.S. The silica stabilized drug-loaded microemulsions were loaded in contact lenses fabricated from pHEMA hydrogel. A layer-by-layer coating of natural polysaccharides using genipin as a cross-linker to sustain the release of diclofenac sodium from the surface of silicone hydrogels and SCL has been reported [, The complex biological process of wound healing in human beings is culminated through well-defined events, namely: coagulation and hemostasis; inflammation, chemotaxis, and activation; proliferation, maturation, and remodeling. Liechty, W.B. The utilization of chitosan as a composite material for hyaluronic-acid-based hydrogel have been studied [, Development of an injectable in situ forming click cross-linked hyaluronic acid hydrogel loaded with chondrogenic differentiation factor, cytomodulin-2, and human periodontal ligament stem cells (hPLSCs) for musculoskeletal application has been described. The hydrogel presented release properties mainly in tissues like digestive tract and open wounds. ; Jeong, B. Biodegradable thermogels. Jacob, S.; Nair, A.B. ; Carvalho, G.C. Barker, K.; Rastogi, S.K. Song, J.; Hwang, S.; Im, K.; Hur, J.; Nam, J.; Hwang, S.; Ahn, G.O. Zhang, Y.; Yang, J.; Zhang, J.; Li, S.; Zheng, L.; Zhang, Y.; Meng, H.; Zhang, X.; Wu, Z. More developments are expected in drug delivery and tissue engineering. Alginate-based composite materials for wound dressing application:A mini review. A vaginal drug delivery system was prepared with flexible propylene glycol-constituting liposomes loaded with metronidazole or clotrimazole dispersed in carbopol hydrogel. Polymer scaffolds are utilized as space filling agents, as delivery vehicles for bioactives, and as three-dimensional structures as reservoirs of cells and growth factors for the formation of desired tissues. Prior to Reading, he worked as a Research Associate in the School of Pharmacy and Pharmaceutical Sciences, University of Manchester (2004–2005), as Research Fellow in the Department of Pharmaceutical Sciences, University of Strathclyde (2002–2004) and as a Lecturer in Polymer Chemistry, al-Farabi Kazakh National University, Kazakhstan (2000–2002). Permeability of moisture and gases through the film for wound dressing is essential to keep the wound comfortable and enhance the healing process. ; Czarnota, G.J. Cellulose is the most abundant biopolymer on Earth, found in trees, waste from agricultural crops and other biomass. Jeon, M.S. The global market for Hydrogel is projected to reach US$15.3 billion by 2025, driven by their growing use in wound care products and drug delivery systems (DDS). Gelatin-based nanoparticles as drug and gene delivery systems: Reviewing three decades of research. ; Liverani, L.; Neščáková, Z.; Boccaccini, A.R. Kamoun, E.A. Azadmanesh, F.; Pourmadadi, M.; Zavar Reza, J.; Yazdian, F.; Omidi, M.; Haghirosadat, B.F. Synthesis of a Novel Nanocomposite Containing Chitosan as a 3D Printed Wound Dressing Technique: Emphasis on Gene Expression. An ideal polymer employed for buccal delivery should have excellent spreadability, swelling, rheological characteristics, adequate bioadhesivity in dry and wet state, mechanical strength, and be non-toxic, economical, biocompatible, and biodegradable [, Buccal films prepared from mucoadhesive polymers like chitosan-carbopol/chitosan-gelation loaded with miconazole nitrate demonstrated excellent in vitro efficacy against Candida species.
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