[2] They are available in multiple lengths and gauge of needle, including 3.5mm, 4mm, 5mm, and 8mm lengths, and 31 through 34 gauge. Your doctor will tell you exactly how to draw both types of insulin into the syringe. [23] For products with included needles, such as epinephrine pens, different brands may have different included needle lengths, which must be taken into account. [10] The higher concentrations are used to lessen the volume of the injection, and allow the same dose of insulin to be injected with less force. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. Some types of insulin need to be gently agitated before injecting. How to use SoloStar Pen for injecting Lantus (Glargine) and Apidra Insulin. Store unopened vials of human insulin, unopened disposable dosing devices and unopened human insulin pens in the refrigerator. Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Human insulin controls high blood sugar but does not cure diabetes. The dose window on the pen shows your insulin dose. Use a different site for each injection, at least 1/2 inch (1.25 centimeters) away from the previous injection site but in the same general area (for example, the thigh). Modify insulin regimens only under medical supervision. (insulin glargine and lixisenatide injection) for subcutaneous use. [27] Historically, pen needles were manufactured in lengths up to 12.7mm. Ask your doctor or pharmacist if you have questions about the type of syringe you should use. Instruction on how to properly attach and use needles is the responsibility of the doctor or pharmacist to ensure proper use. [3] The reduction in number of injections required may decrease the risk of non-adherence due to forgetfulness or unwillingness to self-inject medication. If you are using a regular human insulin (Humulin R, Novolin R), the insulin should be as clear, colorless, and fluid as water. [23], The first injector pen was introduced in 1985, by Novo Nordisk to administer insulin products. Opened vials of human insulin should be stored in the refrigerator but may also be stored at room temperature, in a cool place that is away from heat and direct sunlight. Insulins that are clear in appearance do not require this step. Injection amounts can be different for different pen devices. You can set doses from 1 to 80 units in steps of 1 unit. [11] Combination products are available in fixed-dose ratios and are generally dosed by units of insulin, which will administer a proportional amount of the GLP-1 agonist as well. Be aware that hypoglycemia may affect your ability to perform tasks such as driving and ask your doctor if you need to check your blood sugar before driving or operating machinery. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. for the pens/needles) but resulted in an overall decrease in healthcare costs related to diabetes. For patients using an insulin pen device (cartridge and disposable needles): Change the dose by rotating the head of the pen. Your doctor may tell you to mix two types of insulin in the same syringe. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. Well, after injection, after reapplying the outer pen cap and carefully trying to unscrew both parts off, more othen than not, the outer cap and inner needle NEVER SEEM to reattach into one piece again and unscrew off easily. What side effects can this medication cause? Some pens, including most insulin pens, include dials to adjust the dose of the injection before each administration. ask your doctor how often you should check your blood sugar. What special dietary instructions should I follow? tell your doctor and pharmacist if you are allergic to any type of insulin or any other medications. Be sure to mention any of the following: albuterol (Proair, Proventil, Ventolin, others); alpha blockers such as doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin), tamsulosin (Flomax), and alfuzosin (Uroxatral); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Zestril), moexipril (Univasc), perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); angiotensin receptor blockers (ARB) such as candesartan (Atacand), irbesartan (Avapro), losartan (Cozaar, in Hyzaar), valsartan (Diovan), others; antidepressants; asparaginase (Elspar); atypical antipsychotics such as aripiprazole (Abilify), clozapine (Clozaril, Fazaclo, Versacloz), olanzapine (Zyprexa, in Symbyax), risperidone (Risperdal), others; beta blockers such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), pindolol, propranolol (Inderal), sotalol (Betapace, Sorine), and timolol (Blocadren); clonidine (Catapres, Kapvay); danazol; diazoxide (Proglycem); disopyramide (Norpace); diuretics ('water pills');fibrates such as fenofibrate (Fenoglide, Tricor, Trilipix), fenofibric acid (Fibricor), gemfibrozil (Lopid); isoniazid (in Rifater, Rifamate); lithium; medications for asthma and colds; medications for mental illness or nausea; monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); hormonal contraceptives (birth control pills, patches, rings, injections, or implants); niacin (Niacor, Niaspan, Slo-Niacin); octreotide (Sandostatin);oral medications for diabetes such as pioglitazone (Actos, in Actoplus Met and others) and rosiglitazone (Avandia, in Avandamet and others); oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); pentamidine (Nebupent); pentoxifylline (Pentoxil); pramlintide (Symlin); HIV protease inhibitors (PI) such as atazanavir (Reyataz, in Evotaz), darunavir (Prezista), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir; in Kaletra, Viekira Pak, others); quinine; quinidine; salicylate pain relievers such as aspirin; somatropin (Genotropin, Humatrope, Zomacton, others); sulfa antibiotics; terbutaline (Brethine); and thyroid medications. If your human insulin comes in a disposable dosing device, read the instructions that come with the device carefully. 99 ($0.09/Count) SoloStar is a disposable pen for the injection of insulin. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. [26] Pen adoption in the United States accelerated after studies showed that the higher up-front cost of insulin pens was offset by the increase in compliance, which decreased overall healthcare costs. [3], An injector pen consists of a chamber or cartridge of medication, a tip to attach a needle, and a piston or plunger to inject the dose. [2] Injector pens in general have also been shown to be at least as effective therapeutically as other injection methods. The same insulin pen disassembled, showing replaceable cartridge and reusable housing pieces. Follow these directions carefully. This is especially problematic with injectable medications given the extra work associated with an injection, as well as the potential aversion to self-injecting medication. Your doctor will tell you which type(s) of insulin to use, how much insulin to use, and how often to inject insulin. After fully pressing the plunger button to activate the pen, the button must continue to be held for about 10 seconds to ensure the dose is administered before removing the pen needle from the skin and finally releasing the button. redness, swelling, and itching at the injection site, changes in the feel of your skin, skin thickening (fat build-up), or a little depression in the skin (fat breakdown), large weight gain in a short period of time, swelling of the arms, hands, feet, ankles, or lower legs. If administration by syringe or intravenous injection is necessary, a vial should be used. Talk to your doctor or pharmacist about where on your body you should inject human insulin. [8] Furthermore, pen needles are designed for insertion at a 90-degree angle to the skin, as opposed to normal syringes which are designed to be injected at an angle. Ask your pharmacist any questions you have about refilling your prescription. The primary goal of injector pens is to increase patient adherence by making it easier and more convenient for people to use injectable therapy. Follow these directions carefully. [2] As with insulin vials, some insulin pens are made with higher concentrations including U-200, U-300, and U-500. Studies have shown injector pens to be at least as effective as vial and syringe administration, and surveys have shown that a vast majority of people would prefer an injector pen over vial and syringe administration if one was available. Put the pen next to your skin and press the plunger to inject the medicine. It is also important information to carry with you in case of emergencies. "Lack of Treatment Persistence and Treatment Nonadherence as Barriers to Glycaemic Control in Patients with Type 2 Diabetes", "A review of the new GLP-1 receptor agonist/basal insulin fixed-ratio combination products", "Penetration force and cannula sliding profiles of different pen needles: the PICASSO study", "EADSG Guidelines: Insulin Storage and Optimisation of Injection Technique in Diabetes Management", "Higher concentration insulins: an overview of clinical considerations", "Sanofi Receives FDA Approval of Soliqua 100/33, for the Treatment of Adults with Type 2 Diabetes", "Comparison of Adalimumab Serum Drug Levels When Delivered by Pen Versus Syringe in Patients With Inflammatory Bowel Disease. An injector pen (also called a medication pen) is a device used for injecting medication under the skin. [4], All injector pens other than those designed for single use require the use of single-use replaceable pen needles for each injection. Read the information in this section about the different kinds of insulin devices. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. The types of insulin differ only in how quickly they begin to work and how long they continue to control blood sugar. [2] Dials enable more accurate dose measuring than traditional vial and syringe administration, especially for low doses of insulin. You may give other people a serious infection, or get a serious infection from them. [2] Injector pens designed for single use may also be autoinjectors, which do not require the user to press a plunger to inject the dose. A major barrier to adoption in the United States was the increased up-front cost of insulin pens compared to traditional injections. ", "Insulin delivery using pen devices: Simple-to-use tools may help young and old alike", "Evaluation of a pen injector system for growth hormone treatment", https://en.wikipedia.org/w/index.php?title=Injector_pen&oldid=1000414505, Creative Commons Attribution-ShareAlike License, This page was last edited on 15 January 2021, at 00:39. Many other medications are also available as injector pens, including other injectable medicines for diabetes, high cholesterol, migraine prevention, and other monoclonal antibodies. Use all available sites in the same general area before switching to a different area (for example, the upper arm). Insulin glargine is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. [29], Example of a reusable injector pen used for insulin. The pen plunger moves with each dose. [19] Another medication formulated as an injector pen to ensure quick onset of action is glucagon for hypoglycemia. Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. You can inject your human insulin in the stomach , upper arm, upper leg, or buttocks. Do not use this type of insulin if it appears cloudy, thickened, or colored, or if it has solid particles. Human insulin is used to take the place of insulin that is normally produced by the body. Ask your doctor or pharmacist to show you how to use the device. Each SoloStar contains in total 300 units of insulin. Never share a Fiasp ® FlexTouch ® Pen, PenFill ® cartridge or PenFill ® cartridge device between patients, even if the needle is changed. It is not known if Humalog or Insulin Lispro Injection are safe and effective for children with type 2 diabetes or for children younger than 3 years of age with type 1 diabetes. Follow these directions carefully. An International, Multicentre Cohort Analysis", "Efficacy and safety of adding alirocumab to rosuvastatin versus adding ezetimibe or doubling the rosuvastatin dose in high cardiovascular-risk patients: The ODYSSEY OPTIONS II randomized trial", "Effect of Fremanezumab Compared With Placebo for Prevention of Episodic Migraine: A Randomized Clinical Trial", "The role of basal insulin and GLP-1 receptor agonist combination products in the management of type 2 diabetes", "A portfolio of biologic self-injection devices in rheumatology: how patient involvement in device design can improve treatment experience", "Prefilled pen versus prefilled syringe: a pilot study evaluating two different methods of methotrexate subcutaneous injection in patients with JIA", "Subcutaneous sumatriptan delivery devices: comparative ease of use and preference among migraineurs", "What Can We Learn from Patient-Reported Outcomes of Insulin Pen Devices?
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